From an earlier era of this site. Left here for the record.
Tell if Microsoft Office Save As PDF add in is installed
In this VB.Net Tutorial/Code Example I’m going to show you how to check whether the Microsoft Office 2007 Save As PDF addin (available from here) is installed.
Public Shared Function isPDFSaverInstalled() As Boolean
Dim rtn As Boolean
Dim key As RegistryKey = Registry.LocalMachine.OpenSubKey("SoftwareMicrosoftWindowsCurrentVersionUninstall{90120000-00B0-0409-0000-0000000FF1CE}")
rtn = key IsNot Nothing
key.Close()
Return rtn
End Function